Simplified scheme of APAP metabolism, leading to the formation of NAPQI Download Scientific Diagram Acetaminophen hepatic metabolism #medschool #medstudent #medstudentlife #medicalmnemonics #nurses #usmle #usmlestep1 #usmlestep2 #usmlestep #medicaltalks #medicalstudent #medicalmemes #medicallife #medicalmotivation #usmlepreparation #medreview Biotransformations Leading to Toxic Metabolites: Chemical Aspects ScienceDirect The Hangover Remedy That Can Kill You (Article + Video) Dr. Erica Zelfand Functional Medicine & Integrative Psychiatry Online Appointments Counseling Psychedelic Consultation 3 Glutathione Rescue Normally, glutathione binds NAPQI and converts it into non toxic byproducts (cysteine + mercapturic acid) that are excreted. Example: Glutathione is your liver's safety net against toxins. Alcohol and paracetamol are both processed through the liver. Paracetamol can form a toxic metabolite called NAPQI, which the body usually neutralises safely. But factors like heavy alcohol use, repeated dosing, fasting,