Sex differences in glutathione metabolism and acetaminophen toxicity Automated Screening on REDOX Reactions using the ROXY EC LC System Tylenol Glutathione Kizer Wellness LLC GSH reduces NAPQI, the metabolite responsible for hepatotoxicity in acetaminophen toxicity. Toxic doses increase oxidation into NAPQI, overwhelming glutathione. How does ethanol interfere with acetaminophen metabolism? Image: https: t.co 6EY9dIwLXY The role of oxidative stress, inflammation and acetaminophen exposure from birth to early childhood in the induction of autism Acetaminophen Pathway (toxic doses), Pharmacokinetics