Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health The Hangover Remedy That Can Kill You (Article + Video) Dr. Erica Zelfand Functional Medicine & Integrative Psychiatry Online Appointments Counseling Psychedelic Consultation Unveiling the molecular basis of paracetamol induced hepatotoxicity: Interaction of N acetyl p benzoquinone imine with mitochondrial succinate dehydrogenase ScienceDirect Acetaminophen metabolism Full article: The acetaminophen metabolite N acetyl p benzoquinone imine ( NAPQI) inhibits glutathione synthetase in vitro; a clue to the mechanism of 5 oxoprolinuric acidosis? Alcohol and paracetamol are both processed through the liver. Paracetamol can form a toxic metabolite called NAPQI, which the body usually neutralises safely. But factors like heavy alcohol use, repeated dosing, fasting,