Problem 2: N acetyl para benzoquinone (NAPQI) is an oxidized metabolite of acetaminophen formed in the liver. NAPQI is converted into an acetaminophen glutathione conjugate, a non toxic metabolite Metabolic pathway for NAPQI formation and detoxification by conjugation Download Scientific Diagram Site of Reactivity Models Predict Molecular Reactivity of Diverse Chemicals with Glutathione Chemical Research in Toxicology An Example of a Drug That Causes Toxicity Through the Formation of a Chemically Reactive Intermediate Mechanisms of Adverse Drug Reactions Pharmacovigilance Liver injury induced by paracetamol and challenges associated with intentional and unintentional use Interaction with Ethanol Alcohol Metabolism