Solved The stepwise mechanism below shows how glutathione Chegg.com Fasting depletes Glutathione, turning "safe" Paracetamol doses into a liver toxic emergency. Don't let a therapeutic dose become a lethal one. See the safety protocols on BMJ Best Practice via bio. #MedEd # Pharmacokinetic profile of metabolites by heart cutting two dimensional liquid chromatography: A focus on paracetamol analysis ScienceDirect Acetaminophen (Paracetamol) Toxicity A common and potentially fatal cause of acute liver failure due to toxic accumulation of the metabolite NAPQI when glutathione stores are depleted. Early recognition and timely administration NAPQI Alchetron, The Free Social Encyclopedia NAPQI (N Acetyl 4 benzoquinone Imine) Acetaminophen Metabolite MedChemExpress