Metabolism of acetaminophen (paracetamol) in plantstwo independent pathways result in the formation of a glutathione and a glucose conjugate Environmental Science and Pollution Research Springer Nature Link PharmGKB summary : Pharmacogenetics and Genomics Acetaminophen Metabolism and Toxicity PDF Drug Metabolism Glutathione Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Glutathione: Master Antioxidant, Reducing Oxidative Stress, and Detoxification Full article: Plasma and hepatic concentrations of acetaminophen and its primary conjugates after oral administrations determined in experimental animals and humans and extrapolated by pharmacokinetic modeling