Does Ibuprofen Deplete Glutathione? Understanding the Connection Cymbiotika CYMBIOTIKA Tylenol and Alcohol: Liver Damage Risks & Safety Tips Gratitude Lodge Initial Glutathione Depletion During Short Term Bed Rest: Pinpointing Synthesis and Degradation Checkpoints in the Glutamyl Cycle Exposure to acetaminophen and all its metabolites upon 10, 15, and 20 mg kg intravenous acetaminophen in very preterm infants Pediatric Research Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. MOTRIN PM Pain Relief Caplets MOTRIN