A major breakthrough in brain science is shedding new light on the biology behind depression. Using advanced imaging, researchers have found that people with major depressive disorder have significantly lower levels of Potentiation of glutathione loss and nerve cell death by the transition metals iron and copper: Implications for age related neurodegenerative diseases ScienceDirect Glutathione Metabolism of the BrainThe Role of Astrocytes Dringen 2025 Journal of Neurochemistry Wiley Online Library Changes in levels of the antioxidant glutathione in brain and blood across the age span of healthy adults: A systematic review ScienceDirect Neuronal glutathione loss leads to neurodegeneration involving gasdermin activation Scientific Reports Glutathione Supplement Glutathione Antioxidant BrainMD BrainMD