Which analgesic causes liver toxicity? Tylenol and glutathione, actually explainedhere's the bullet points: * Lots of concern raised on social media re: glutathione depletion and acetaminophen use * Glutathione is used in the metabolism of acetaminophen and Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. How NSAIDs Affect Glutathione Levels Pure TheraPro Rx Does Ibuprofen Deplete Glutathione? Understanding the Connection Cymbiotika CYMBIOTIKA Is Acetaminophen or Ibuprofen better for kids? THE PEDIATRICIAN MOM