Paracetamol (Acetaminophen) hepatotoxicity and its management. Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: How Dangerous is Tylenol? Taking Tylenol? The Glutathione Connection Dr. Green Mom Sex differences in glutathione metabolism and acetaminophen toxicity