Mast cells are hypersensitive immune cells that release histamine and other inflammatory mediatorsoften in response to oxidative stress, environmental toxins, and immune imbalance. Many patients with MCAS have low levels of glutathione. Mast cells are hypersensitive immune cells that release histamine and other inflammatory mediatorsoften in response to oxidative stress, environmental toxins, and immune imbalance. Many patients with MCAS have low levels of glutathione. How Mycotoxins Trigger Mast Cell Activation and Brain Inflammation FOXO regulation of TXNIP induces ferroptosis in satellite cells by inhibiting glutathione metabolism, promoting Sarcopenia Cellular and Molecular Life Sciences Springer Nature Link Mast cell activation may underlie inflammation in severe COVID 19 A New Stage for Seasoned Actors Food Anaphylaxis and the Cysteinyl Leukotrienes New England Journal of Medicine