071 Phospholipase C Pathway DAG and IP (B), Phosphatidylinositol 4,5 bisphosphate (PIP) is cleaved by phospholipase C following activation of Gq coupled receptors. This reaction produces diacylglycerol (DAG), which remains in File:Activation protein kinase C.svg Wikimedia Commons Phosphoinositide phospholipase C Wikipedia The Cryptococcal Enzyme Inositol Phosphosphingolipid Phospholipase C Confers Resistance to the Antifungal Effects of Macrophages and Promotes Fungal Dissemination to the Central Nervous System Infection and Immunity When a signaling molecule, such as a hormone, binds to a Gq coupled receptor on the cell surface, it activates a G protein of the Gq type. This, in turn, activates an enzyme