Alcohol and paracetamol are both processed through the liver. Paracetamol can form a toxic metabolite called NAPQI, which the body usually neutralises safely. But factors like heavy alcohol use, repeated dosing, fasting, Acetaminophen Toxicity: How Genetic Susceptibility Combines with Environmental Factors TOXICOLOGY PARACETAMOL POISONING What Are the Potential Sites of Protein Arylation by N Acetyl p benzoquinone Imine (NAPQI)? Chemical Research in Toxicology Problem 2: N acetyl para benzoquinone (NAPQI) is an oxidized Clinical toxicity of Acetaminophen