Interaction with Ethanol Alcohol Metabolism Acetaminophen's Role in Autism and ADHD: A Mitochondrial Perspective Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Tylenol Glutathione Kizer Wellness LLC Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Functional neurologist discusses Tylenol use after President Trump's big announcement linking Tylenol to autism