Glutathione is such a critical soldier in our line of defense that our bodies make it themselves. We even have mechanisms that recycle and reuse it. But what happens when our toxic L Glutathione reduced, 70 18 8, G4251, Sigma Aldrich A 48 hour fast can turn standard Paracetamol into acute liver failure. Fasting depletes Glutathione, leaving the liver defenseless against toxic NAPQI. Review the latest guidelines on BMJ Best Practice: https: bestpractice.bmj.com topics en us 1010 Sex differences in glutathione metabolism and acetaminophen toxicity Reduced L Glutathione 150mg Reducing the effects of drug toxicity on glutathione metabolism ScienceDirect