Why you should avoid REGULAR acetaminophen use for babies and pregnancy 3 Little Plums Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Metabolism of acetaminophen (paracetamol) in plantstwo independent pathways result in the formation of a glutathione and a glucose conjugate Environmental Science and Pollution Research Springer Nature Link Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health Don't Suppress a Fever Acetaminophen toxicity EMCrit Project