Tylenol, Autism, And The Glutathione Connection OC Integrative Medicine Tylenol's Impact on Glutathione and Liver Damage Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Glutathione, Tylenol, and Vaccines: What Parents Need to Know Lotus Homeopathy, Inc. Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: They told us Tylenol is safe. Pediatricians recommend them daily. But what if we've been missing the full story? Research shows that frequent use of acetaminophen (Tylenol) in babies and children