Pathology of G6PD deficiency Pathology Made Simple Glucose 6 Phosphate Dehydrogenase: Update and Analysis of New Mutations around the World Metabolism: The pentose phosphate pathway and G6PD deficiency (practice) Khan Academy G6PD Deficiency Glucose 6 phosphate dehydrogenase deficiency X linked recessive disorder Leads to low NADPH, impairing glutathione regeneration RBCs are vulnerable to oxidative damage Pathophysiology: In G6PD deficiency: No Blister Cell in G6PD Deficiency , Red Blood Cell with a clear vacuole like area on its membrane, resembling a blister., It usually results when splenic macrophages remove precipitated Heinz Glucose 6 Phosphate Dehydrogenase Deficiency Hematology & Oncology UWorld Medical Library