Dihexa (also known as PNB 0408) is an experimental small molecule derived from angiotensin IV. It was engineered to cross the bloodbrain barrier and has shown synaptogenic effects in preclinical models. The often quoted Dihexa is concentrated in multiple brain regions. Rats fitted with a Download Scientific Diagram Could a tiny peptide actually help your brain form new connections? Meet Dihexa now available OTC in NEUROgevity. Originally designed for Alzheimers, it promotes neuroplasticity, supports mental AngIV Analog Dihexa Rescues Cognitive Impairment and Recovers Memory in the APP PS1 Mouse via the PI3K AKT Signaling Pathway Growth factors and their peptide mimetics for treatment of traumatic brain injury ScienceDirect Dihexa in Clinical Trials: What We've Learned So Far