Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Deficient Glutathione in the Pathophysiology of Mycotoxin Related Illness 15 Glutathione Benefits: How to Improve Your Mind & Body Glutathione Depletion and Stalwart Anticancer Activity of Metallotherapeutics Inducing Programmed Cell Death: Opening a New Window for Cancer Therapy ACS Omega Glutathione Deficiency Symptoms: Is Poor Sleep Just the Beginning? Cardiology & Neurology Specialists located in Queens, Forest Hills and Brighton Beach, Brooklyn, NY Advanced Medical Care Does Ibuprofen Deplete Glutathione? Understanding the Connection Cymbiotika CYMBIOTIKA