A 48 hour fast can turn standard Paracetamol into acute liver failure. Fasting depletes Glutathione, leaving the liver defenseless against toxic NAPQI. Review the latest guidelines on BMJ Best Practice: https: bestpractice.bmj.com topics en us 1010 Pharmacology 401 k Paracetamol NAPQI Glutathione COX3 Poisoning Antidote AcetylCysteine YouTube Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Good ol' paracetamol: 'But an overconsumption takes its toll' Journal of Anaesthesia Practice The gamma glutamyl pathway after glutathione depletion due to Download Scientific Diagram Drug Related Pyroglutamic Acidosis: Systematic Literature Review