Researchers are studying a possible link between acetaminophen (Tylenol) use during pregnancy and higher autism or ADHD risk. It may lower glutathione, an important antioxidant for brain development. Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. The Truth About Paracetamol and Glutathione Levels Tylenol's Impact on Glutathione and Liver Damage Acetaminophen Toxicity: How Genetic Susceptibility Combines with Environmental Factors Acetaminophen, a Therapeutic or an Extremely Toxic RemedyA Review