Acetaminophen Toxicity: How Genetic Susceptibility Combines with Environmental Factors Minor and Short Acting Analgesics, Including Opioid Combination Products Anesthesia Key Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Did you know that high doses of paracetamol can be toxic to your liver? Paracetamol, also known as acetaminophen, is a commonly used painkiller that can have harmful effects on the body Conjugation With Glutathione and Mercapturic Acid Formation Biotransformation of Drugs STUDENT CONSULT (ver. 2.3)