A 48 hour fast can turn standard Paracetamol into acute liver failure. Fasting depletes Glutathione, leaving the liver defenseless against toxic NAPQI. Review the latest guidelines on BMJ Best Practice: https: bestpractice.bmj.com topics en us 1010 Accidental paracetamol poisoning The Medical Journal of Australia Silymarin prevents acetaminophen induced hepatotoxicity via up regulation of the glutathione conjugation capacity in mice ScienceDirect Frontiers Glutathione deficiency in the pathogenesis of SARS CoV 2 infection and its effects upon the host immune response in severe COVID 19 disease Exposure to acetaminophen and all its metabolites upon 10, 15, and 20 mg kg intravenous acetaminophen in very preterm infants Pediatric Research Sanghuangporus sanghuang Mycelium Prevents Paracetamol Induced Hepatotoxicity through Regulating the MAPK NF B, Keap1 Nrf2 HO 1, TLR4 PI3K Akt, and CaMKK LKB1 AMPK Pathways and Suppressing Oxidative Stress and Inflammation