CLINICAL REVIEW Frontiers MitochondrialLysosomal Axis in Acetaminophen Hepatotoxicity An Example of a Drug That Causes Toxicity Through the Formation of a Chemically Reactive Intermediate Mechanisms of Adverse Drug Reactions Pharmacovigilance Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. The gamma glutamyl pathway after glutathione depletion due to Download Scientific Diagram Oxidative stress during acetaminophen hepatotoxicity: Sources, pathophysiological role and therapeutic potential ScienceDirect