Acetaminophen detoxification in cucumber plants via induction of glutathione S transferases ScienceDirect Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health TYLENOL [Acetaminophen] metabolism A lot of GLUTATHIONE is needed to deal with the Oxidative Stress generated by the CYP 450 metabolism of Tylenol. When people go to the ER for Tylenol Overdose About Acetaminophen Overdose Can Tylenol (acetaminophen) deplete glutathione levels in the body? The FDA is signaling that perhaps immediate treatment with acetaminophen is less clearly needed for a low grade fever, especially in pregnancy, unless theres a stronger indication for it., Safer