Full article: Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease Perinatal exposure to paracetamol: Dose and sex dependent effects in behaviour and brain's oxidative stress markers in progeny ScienceDirect The Metabolism of Acetaminophen and the Synthesis of Glutathione Download Scientific Diagram Too much paracetamol = dangerous because of how your liver processes it. *Normal dose:* About 90 95% gets broken down safely by glucuronidation + sulfation non toxic stuff you pee out. *The problem An Example of a Drug That Causes Toxicity Through the Formation of a Chemically Reactive Intermediate Mechanisms of Adverse Drug Reactions Pharmacovigilance Frontiers Acetaminophen induced liver injury: Molecular mechanism and treatments from natural products