An Example of a Drug That Causes Toxicity Through the Formation of a Chemically Reactive Intermediate Mechanisms of Adverse Drug Reactions Pharmacovigilance A 48 hour fast can turn standard Paracetamol into acute liver failure. Fasting depletes Glutathione, leaving the liver defenseless against toxic NAPQI. Review the latest guidelines on BMJ Best Practice: https: bestpractice.bmj.com topics en us 1010 Acquired pyroglutamic acidosis due to long term dicloxacillin and paracetamol use BMJ Case Reports Acetaminophen's Role in Autism and ADHD: A Mitochondrial Perspective Combination of Paracetamol and the Glutathione Depleting Agent Buthionine Sulfoximine Show Differential Effect on Liver Cancer Cells and Normal Hepatocytes Longterm adverse effects of paracetamol a review McCrae 2018 British Journal of Clinical Pharmacology Wiley Online Library